INDUSTRIAL EXPERIENCE WITH OXYGEN CONTROL OF A FED-BATCH FILAMENTOUS FUNGAL FERMENTATION
نویسندگان
چکیده
منابع مشابه
Industrial Experience with Oxygen Control of a Fed-batch Filamentous Fungal Fermentation
Fed-batch filamentous fungal fermentations at the industrial level are operated today either in an open-loop manner or through simple PI control, both with limited performance. The main challenge presented by such an operation is that, due to the presence of uncertainties of the inoculum, the process can go into oxygen limitation that severely affects production. In this paper, a cascade contro...
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Industrial filamentous fungal fermentations are typically operated in fed-batch mode. Oxygen control represents an important operational challenge due to the varying biomass concentration. In this study, oxygen control is implemented by manipulating the substrate feed rate, i.e. the rate of oxygen consumption. It turns out that the setpoint for dissolved oxygen represents a trade-off since a lo...
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A nonlinear dynamical system, in which the feed rates of glycerol and alkali are taken as the control functions, is first proposed to formulate the fed-batch culture of 1,3-propanediol 1,3-PD production. To maximize the 1,3-PD concentration at the terminal time, a constrained optimal control model is then presented. A solution approach is developed to seek the optimal feed rates based on contro...
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ژورنال
عنوان ژورنال: IFAC Proceedings Volumes
سال: 2005
ISSN: 1474-6670
DOI: 10.3182/20050703-6-cz-1902.01577